Overcoming the Limits of Flash Nanoprecipitation: Effective Loading of Hydrophilic Drug into Polymeric Nanoparticles with Controlled Structure.

Polymers (Basel) · 2018 · PMC6403626 · PMID 30961017

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an increasing trendno p-value reported

As far as the LC of caffeine-in-water formulations was concerned, an increasing trend with MR was observed, suggesting that the LC can be controlled by adjusting the relative content of caffeine and PCL.

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a clear trendno p-value reported

EE values did not show a clear trend with the MR in both cases, but a 5%–10% higher value was observed when water was used as the solvent.

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