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Tracking dengue virus type 1 genetic diversity during lineage replacement in an hyperendemic area in Colombia.

PLoS One · 2019 · PMC6405123 · PMID 30845200

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showed a trendno p-value reported
Pooling all samples showed a trend toward higher πN/πS ratios in non-structural genes vs. structural genes, consistent with the idea that structural genes may be under stronger purifying selection than nonstructural genes.

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