Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy.

In contrast, the expression of the proliferation marker Ki67 was increased on iNKT cell in all organs of C20:2 treated mice, while a clear trend of increase in Ki67 in iNKT cells was seen in spleen and MLN after treatment with C26:0 ( Figure 4H ).

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Thus, we demonstrate that short-term treatment with C20:2 resulted in a highly significant anti-tumor effect in the Apc Min /+ tumor model, while short-term treatment with C26:0 did not have as potent anti-tumor effect as in long-term treatment.

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