The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.

Gene expression levels of regulators of mitochondrial fission were reduced 30 h after exercise in TRN animals ( P < 0.05, Figure 3 B), whereas expression levels of mitochondrial fusion, mitophagy, and autophagy genes were elevated but most failed to reach significance ( P > 0.05, Figure 3 B).

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Although we observed a shift in the molecular weight distribution of the outer mitochondrial membrane (OMM) potential-sensitive Ser–Thr kinase PINK1 at EX90 and during the recovery period, the difference from SED did not reach statistical significance ( Supplemental Figure 1A ).

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