The role of CEA, CYFRA21-1 and NSE in monitoring tumor response to Nivolumab in advanced non-small cell lung cancer (NSCLC) patients.

J Transl Med · 2019 · PMC6408784 · PMID 30849967

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highly significantno p-value reported

However, the correlation of the CEA and CYFRA21-1 reduction ≥ 20% with DCR and longer PFS was highly significant.

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a significant trendno p-value reported

Specifically, in the multivariate analysis the CYFRA21-1 reduction ≥ 20% contributed significantly to the prediction of PFS and had a significant trend towards a positive prognostic factor.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.