Determinants of submaximal exercise capacity in patients at risk for heart failure with preserved ejection fraction-results from the DIAST-CHF study.

Biomarkers of impaired exercise capacity rInterestingly, we found a highly significant association between submaximal exercise capacity and biomarkers of neurohumoral activation.

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There was a significant trend towards lower 6 min walk distances with increasing DD class obtained at rest: 570 ± 78 m for normal diastolic function (N) versus 511 ± 114 m for DD without elevated filling pressures and 492 ± 111 m for DD with elevated filling pressures (Figure 1 ).

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