Transmissible ER stress reconfigures the AML bone marrow compartment.

These OPC differences were significant in Molm-14 and U937 xenografts, and did not reach statistical significance for HL-60 xenografts.

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To better correlate the magnitude of UPR induction in patients with our xenograft results, we also performed an additional transcriptional analysis of GRP78 , s/usXBP1 and CHOP expression in these patient samples and found highly significant differences from healthy control bone marrows ( Figure 5g ).

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