HLA-C-restricted viral epitopes are associated with an escape mechanism from KIR2DL2⁺ NK cells in Lassa virus infection.

While the data did not reach statistical significance (due to the small proportion of fatalities in LASV) they suggested that HLA-C1 : KIR2DL2 interaction could certainly participate to the fatal outcome LASV infection. 3.2 Identification of KIR/HLA class-1 associated epitopes within GP and NP LASV proteins We next investigated whether peptides from GP and NP LASV proteins presented by HLA class-1 molecules on target cells can impact NK cell function through HLA-C1:KIR2DL2 interaction.

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