HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis.

CD4+ T cell loss is highly significant in the interstitium but not the alveolar space, and loss of interstitial CD4+ T cells is associated with extrapulmonary dissemination of M. tuberculosis . pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manusc

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Lung interstitial CD4+ T cell loss was significantly higher compared with paired BAL samples ( Figure 5D ), and BAL CD8+ T cell numbers showed a trend of increased numbers in SIV-co-infected compared with SIV-uninfected animals ( Figure S5G ).

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