"Physiological Dysregulation" as a Promising Measure of Robustness and Resilience in Studies of Aging and a New Indicator of Preclinical Disease.

The results indicate that measures of PD (D M ) constructed using data on biomarkers in two longitudinal studies (FRAMCOHORT and CHS) and two distinct reference populations (ages at baseline below 40 in FRAMCOHORT and 65–70 in CHS) show significant negative effect on onsets of “unhealthy life” (proxy for robustness), survival following onset of “unhealthy life” (proxy for resilience; however, it is only marginally significant in CHS), and total mortality in the Cox regression analyses.

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