CD8<sup>+</sup> cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy.

Oncoimmunology · 2019 · PMC6422383 · PMID 30906657

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did not reach statistical significanceno p-value reported

By day 21 all five elderly mice had weak but detectable CTL responses to SIINFEKL, however the differences in CTL lysis did not reach statistical significance.

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