showed a trendP = 0.08
chemotherapy with adjuvant chemotherapy showed a trend toward improvement in overall survival (HR 0.70; 95% CI 0.47‐1.04; P = 0.08). 61 Ishigami et al. conducted a phase III trial comparing i.p. and i.v. paclitaxel plus S‐1 (IP) versus cisplatin plus S‐1 (SP) in patients with peritoneal metastasis. 62 Although this trial failed to show statistical superiority of intraperitoneal paclitaxel plus systemic chemotherapy, the 3‐year overall survival rate was 21.9% (95% CI, 14.9%‐29.9%) in the IP arm and 6.0% (95% CI, 1.6%‐14.9%) in the SP arm.