Divergent effects of repeated cocaine and novel environment exposure on locus coeruleus c-fos expression and brain catecholamine concentrations in rats.

In the EPM, cocaine‐exposed rats showed a strong trend toward an increase in arm entries over saline‐exposed rats, although this effect did not reach significance ( p = 0.054; Figure 2 d), and spent a significantly greater amount of time in the open arms than did saline‐exposed rats ( p = 0.024; Figure 2 e).

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