a marked trendP < 0.001
By multivariate analysis, the clinical response to high-dose etoposide was demonstrated to have a significant impact or a marked trend toward a higher CR achievement (OR, 2.331 (1.481–3.891), P < 0.001), longer PFS (HR, 0.210 (0.069–0.643), P = 0.006), and OS (HR, 0.183 (0.062–0.543), P = 0.002).