Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.

During Probe test 1, although differences in the number of platform crossings between WT and App NL - G - F/NL - G - F mice did not reach statistical significance (Fig. 2 b; F [2, 41] = 2.95, p = 0.064), App NL - G - F/NL - G - F mice exhibited significantly longer proximity to the platform than WT mice (Fig. 2 c; F [2, 41] = 5.61, p = 0.007, post hoc, WT vs.

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