Attenuated Oral Typhoid Vaccine Ty21a Elicits Lamina Propria and Intra-Epithelial Lymphocyte Tissue-Resident Effector Memory CD8 T Responses in the Human Terminal Ileum.

We also noted that IEL CD8+ T RM appear to show some increases in the production of IFN-γ and IL-2 cytokine following Ty21a-vaccination in some volunteers, which, as a group, did not reach statistical significance ( Figure 11A ).

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