Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis.

Gene Set Analysis Primary Analysis of Voltage-Gated Sodium and Calcium Channels We found nominally significant evidence for enrichment in cases for LoF variants (frequency <0.1%) in voltage-gated sodium channels (targeted sequencing sample: OR, 1.99; 95% CI, 1.11–3.71; p = .02; p corrected = .08; case-control-de novo meta-analysis: p = .025; p corrected = .1) ( Table S4 in Supplement 2 ), but no evidence for association between schizophrenia and voltage-gated calcium channels ( Table S4 in Supplement 2 ).

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