Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials.

However, among participants with no history of vascular disease, we observed a significant trend towards smaller proportional risk reductions with increasing age (p trend =0·05; figure 4 ), which persisted after exclusion of the heart failure and dialysis trials (p trend =0·03; appendix ).

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Older age groups were disproportionately represented in heart failure and dialysis trials (which did not show an overall benefit with statin therapy), and exclusion of those trials weakened an apparent trend with increasing age towards smaller relative risk reductions in vascular event and mortality outcomes.

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We observed significant efficacy regardless of age among participants with previous vascular disease, whereas there was a weak trend towards smaller relative risk reductions with increasing age in the primary prevention setting (although there were too few such older participants for reliable assessment in that group alone).

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