Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.

In the current study, we demonstrate nominally significant hypermethylation at both loci (Fig. 4 a: cg05066959: ∆ = 13.10, P = 1.13 × 10 −4 and Fig. 4 b: cg11823178: ∆ = 9.39, P = 5.48 × 10 −5 ), in parallel with a nominally significant decrease in uC (cg11823178: ∆ = − 5.03, P = 1.19 × 10 −3 ; cg05066959: ∆ = − 9.06, P = 1.18 × 10 −4 ), and a nominally significant decrease in 5hmC at cg11823178 (∆ = − 4.36, P = 0.02), with a non-significant decrease in 5hmC at cg05066959 ( ∆ = − 4.04, P = 0.14).

also in 7,732 other papers