Nominally significant polygenic signal for the meta-analysis of unrelated AA individuals was observed based on LDSR with scores computed from 1000 Genomes African populations (z = 2.12, p = 0.017), but the quantitative estimate of h 2 g was unstable depending on the choice of reference panel, reflecting the challenge of correctly specifying LDSR and robustly modelling LD for the AA population ( Supplementary Information A11 ).
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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.
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