Combining anti-IL-7Rα antibodies with autoantigen-specific immunotherapy enhances non-specific cytokine production but fails to prevent Type 1 Diabetes.

PLoS One · 2019 · PMC6433345 · PMID 30908554

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Histological analysis of islet infiltration in the protected animals of both treatment groups revealed no major differences in overall numbers of insulitic islets, albeit that mice receiving anti-IL-7Rα mAbs showed a trend towards more severe immune cell infiltration per islet ( Fig 5B and 5C ).

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