Consequently, while the uptake in hearts, lungs and brains of 9-week-old Npc1 − / − mice was higher than that in WT mice (by 42, 43 and 29% respectively) whether measured by PET or ex vivo organ counting, the differences measured by PET did not reach statistical significance.
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Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography.
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