Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.

5B ), with borderline significance in the VDB (Fig. 5C ).

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A less robust loss of synaptophysin was seen in the striatum in the aged mice (76.1 ± 7.7% of young mice) which increased with LM11A-31 (91.3 ± 7.2% of young mice) but failed to reach significance due in part to the smaller initial deficit and greater variation.

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LM11A-31 significantly reduced the overall loss of cholinergic cell area from −26.6 + 3.8% to −10.1 + 5.5% (MS + VDB) and though similar changes were seen in individual regions, these fell short of significance.

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Thus, while there were decreases in cell counts at 18 and 25 months, these did not reach statistical significance.

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