Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer.

Stroma-high tumors tended to have an increased expression of FAP (M low = 0.048, SE = 0.019; M high = 0.073, SE = 0.026) and a lower expression of CD31 (M low = 0.013, SE = 0.004; M high = 0.004, SE = 0.001) relative to the total amount of stroma, although the difference did not reach statistical significance (Fig. 3 a).

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