Semi-solid prodrug nanoparticles for long-acting delivery of water-soluble antiretroviral drugs within combination HIV therapies.

The 672 candidates were ranked against these targets and a clear trend of the number of hits was observed across the 16 prodrugs; relatively few hits were observed for compounds 1 – 3 and 9 – 16 , with over half of the potential candidates producing hits for compounds 4 – 8 bearing masking groups at both 5’-hydroxyl and amino groups (Fig. 3a ).

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