Barely Significant
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Interplay between DNA sequence and negative superhelicity drives R-loop structures.

Proc Natl Acad Sci U S A · 2019 · PMC6442632 · PMID 30850542

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a clear trendno p-value reported
A clear trend for formation in close proximity to the TSS was also revealed, suggesting that suboptimal R-loops may form before transcription has reached more favorable downstream sequences.

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