Mendelian Randomization Analysis Support Causal Associations of HbA1c with Circulating Triglyceride, Total and Low-density Lipoprotein Cholesterol in a Chinese Population.

In non-diabetic participants (n = 8610), though the associations of the two GRSs with the four lipids were weakened, the results of causal association analyses were consistent with the analyses in the whole study sample, except for TC which was marginally significant in analysis with the Conservative GRS ( P = 0.05) (Supplemental Table 6 ).

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All Outcomes from MR-Egger method were failed to reach statistical significance, but the beta-coefficients for TG, TC, and LDL-C were approaching with those from the other methods; the intercepts of MR-Egger were all insignificant, which indicated no directional pleiotropy.

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