Mimicking the physical cues of the ECM in angiogenic biomaterials.

It is possible that the positive correlation between matrix density and branching revealed by RIMAC may be attributed to the relative simplicity of the platform; for example, the other models described in this review add supporting cell types and more closely mimic physiological vasculogenic/angiogenic processes. Nevertheless, these studies have revealed a clear trend: lower structural ECM protein concentrations allow ECs to proliferate and migrate more quickly in 3D microenvironments, thereby enabling the formation of vascular networks.

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Second, we note that a definite trend that only appears in 2D culture could be misleading.

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