Body mass index, mammographic density, and breast cancer risk by estrogen receptor subtype.

Breast Cancer Res · 2019 · PMC6448282 · PMID 30944014

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of borderline significanceno p-value reported

Elevated percent density was associated with increased risk of both ER-positive and ER-negative cancers in premenopausal and postmenopausal women, although the association between percent density and ER-negative cancers was of borderline significance in HT users.

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did not reach statistical significanceno p-value reported

Postmenopausal HT non-users who were overweight/obese also had increased risk of ER-negative cancer [OR 1.62 (95% CI 1.06–2.94)] and ER-positive cancer [OR 2.28 (95% CI 1.86–2.81)] relative to their normal/underweight counterparts, though the heterogeneity of ER subtype-specific risk did not reach statistical significance ( P het = 0.13).

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