Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids.

Consistent with these findings, protein analysis demonstrated increased levels of Lp-PLA2 in individuals with type 2 diabetes; however, this increase was more modest and did not reach statistical significance (Fig. 3 b).

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While still appreciating that downregulating Lp-PLA2 in adipocytes may be significant in reducing systemic triacylglycerols and oxLDL levels, it should be stressed that, as lipid control is a multifactorial process, examining more than one mediator would enhance our understanding of the potential impact on lipid profiles.

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