Predictive factors for long-term responders of pemetrexed maintenance treatment in non-small cell lung cancer.

Predictive factors for extreme responders When subgroups were created to identify extremely poor (≤ 7 cycles, F7) and good (≥ 20, M20) responders, the M20 group showed a trend similar to that of the M10 group with higher numbers of M1a stage patients (42.3% vs. 20.8%; P = 0.024), a lower incidence of brain metastasis (23.1% vs. 42.6%; P = 0.069), and lower levels of TS expression (median H‐score 5.0% vs. 50.0%; P = 0.030) (Fig 2 b, Table 2 ).

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