NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients.

NPJ Breast Cancer · 2019 · PMC6450950 · PMID 30963110

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did not reach statistical significanceno p-value reported

Although the size of our cohort was limited to 61 patients and OS did not reach statistical significance, the 5-year distant metastasis-free survival (DMFS) rate of patients with NDRG4-methylated tumors was significantly lower than that of patients with unmethylated tumors (20% versus 76.1% respectively, HR = 0.1, p < 0.001, Fig. 3b and Supplementary Data 4 ).

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