The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα.

On the contrary, the lactate levels were decreased albeit did not reach statistical significance in the plasma of fed Vps15-LKO mice (P value of 0.059, unpaired two-tailed Student’s t-test) and fasting further lowered it in both genotypes (Supplementary Fig. 4e ).

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