A robust pipeline with high replication rate for detection of somatic variants in the adaptive immune system as a source of common genetic variation in autoimmune disease.

Hum Mol Genet · 2019 · PMC6452186 · PMID 30541027

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0.0570

closest p · 1.1× alpha

0.0570

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showed a trendP = 0.057so close (0.05 < p ≤ 0.1)

Somatic variants showed a trend for being more damaging as reflected by the phred-scaled combined annotation-dependent depletion (CADD) score ( P = 0.057; Fig. 4B ) and for being located at more conserved positions as indicated by the genomic evolutionary rate profiling (GERP) score ( P = 0.062; Fig. 4C ).

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