The presence of MSC-differentiated adipocytes showed a trend of increased tumor growth over the 35-day follow-up period while blockade of exosome generation with GW4869 seemed to reduce tumor-promoting effects of MSC-differentiated adipocytes (Fig. 5 a–d).
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Exosomes secreted by mesenchymal stromal/stem cell-derived adipocytes promote breast cancer cell growth via activation of Hippo signaling pathway.
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