Although the p53 MO-mediated rescue of atp6v1aa + ionocyte cell density did not reach statistical significance, injection of downstream cdkn1a MO did produce a significant rescue effect on atp6v1aa + ionocyte cell density of klf4 morphants at 24 hpf ( S13 Fig ).
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Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition.
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