A specific amino acid motif of <i>HLA-DRB1</i> mediates risk and interacts with smoking history in Parkinson's disease.

Proc Natl Acad Sci U S A · 2019 · PMC6462083 · PMID 30910980

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hedged sentences

0.0120

closest p · 0.2× alpha

0.0600

boldest claim

The sentences

borderline significanceP = 0.012actually significant

Complementing this finding, we observed borderline significance for PD risk mediated by HLA-DRB1*01:01 ( P = 0.012; OR, 1.26; 95% CI, 1.05–1.50).

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a strong trendP = 0.06so close (0.05 < p ≤ 0.1)

Likewise, the interaction term for a negative history of smoking with homozygosity for SE + V11 − alleles also showed a strong trend ( P = 0.06), and we found that a history of having never smoked in combination with SE + V11 − alleles are predisposing to PD ( P = 0.01; OR, 1.51; 95% CI, 1.08–2.12), with a greater effect size than for HLA alone (OR, 1.29; 95% CI, 1.01–1.66).

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