Nuclear receptor gene polymorphisms and warfarin dose requirements in the Quebec Warfarin Cohort.

Previously known VDR polymorphisms FokI (rs2228570; P = 0.54), ApaI (rs7975232; P = 0.60), TaqI (rs731236; P = 0.16), and BsmI (rs1544410; P = 0.29) did not reach statistical significance, as shown in Supplementary File 1 .

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Principal components C1–C4 to control for population stratification were added to the model as well as target INR which although only borderline significant, can influence target dose, as well as CYP2C9/VKORC1 metabolizer phenotypes, which are well-established predictors of warfarin dose requirements (Supplementary File 2 , Table 2 ).

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