Current Progress in Pharmacogenetics of Second-Line Antidiabetic Medications: Towards Precision Medicine for Type 2 Diabetes.

Although modest alterations in the maximum plasma concentration (C max ), area under the plasma concentration–time curve (AUC), renal clearance (CL R ), and fraction excreted unchanged in the urine (f e ) of sitagliptin were observed in ABCB1 TTT/TTT diplotype subjects ( n = 10) and, compared with the two other diplotype groups ( n = 9 for CGC/CGC; n = 10 for CGC/TTT), all differences did not reach statistical significance.

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