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Immune Response of <i>Galleria mellonella</i> against Human Fungal Pathogens.

J Fungi (Basel) · 2018 · PMC6463112 · PMID 30587801

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a strong trendno p-value reported
To reduce these bioethical problems, there is a strong trend to apply the “3 Rs” rule in experiments that involve animal use, which are: reduce the numbers of animals; refine the protocols to increase animal comfort and reduce pain; replace animals for other models that do not have bioethical problems associated [ 1 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.