Submolecular dissection reveals strong and specific binding of polyamide-pyridostatin conjugates to human telomere interface.

From the potency of the polymerase-stop effect, we also roughly estimated the dissociation constant ( K d ), which showed a trend in qualitative agreement with single molecule measurements ( K d = 240 ± 80 nM for PDS , K d = 50 ± 30 nM for TH59b , and K d = 20 ± 10 nM for TH59b-SL-PDS , Supplementary Figure S18B ).

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