Overactive IGF1/Insulin Receptors and NRASQ61R Mutation Drive Mechanisms of Resistance to Pazopanib and Define Rational Combination Strategies to Treat Synovial Sarcoma.

Cancers (Basel) · 2019 · PMC6468361 · PMID 30909453

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0590

boldest claim

The sentences

highly significantp = 0.001actually significant

Kaplan Meier analysis considering tumor size exceeding 800 mm 3 as an endpoint showed a highly significant difference between curves ( p = 0.001) ( Figure 6 A,B).

also in 132,142 other papers

approximating significancep = 0.059so close (0.05 < p ≤ 0.1)

At the end of the experiment (day 57), all mice receiving a single drug treatment had measurable tumors, and a similar tumor volume inhibition (TVI) (43%) was achieved in both groups barely approximating significance ( p = 0.059 trametinib, p = 0.053 pazopanib).

also in 6 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.