The log-rank (Mantel–Cox) test was found to be approximating significance ( P = .053).
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“approximating significance”
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At the end of the experiment (day 57), all mice receiving a single drug treatment had measurable tumors, and a similar tumor volume inhibition (TVI) (43%) was achieved in both groups barely approximating significance ( p = 0.059 trametinib, p = 0.053 pazopanib).
As for OS, 320 GA patients had OS information, and the overall hazard ratio (HR) was 0.638 (95% confidence interval [CI]: 0.401–1.013, p = 0.057), approximating significance.
However, none of the correlations with the ADOS-2 scores or with ADI-R at the 10- and 14-month visits were approximating significance ( Supplemental material Table S3 ).
Approximating significance via permutation, we identify sets with significantly high pathway centrality as functional mediating pathways.
Multivariate analysis showed approximating significance with p = 0.05. 3.4.
This observation demonstrates that the principled way of hierarchically approximating significance for groups of loci adds value to the exploitation of genomic redundancies.