showed a trendp = 0.098
A meta-analysis where the prior cohort study was excluded, showed a trend towards reduced risk of OC with tubal-ligation in BRCA 1 mutation carriers (odds ratio 0.69, p = 0.098), but not in BRCA 2 mutation carriers (odds ratio 0.73, p = 0.33), likely due to small number [ 42 ].