Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging.

The Trk inhibitor landscape was however rapidly moving from exploratory tool inhibitor (such as GW441756 ) to more relevant drug leads and there was a clear trend in preclinical work and patent literature towards what has now become one of the most explored chemotypes, specifically imidazo[1,2- b ]pyridazine and pyrazolo[1,5-a]pyrimidine-based inhibitors ( Figure 4 ).

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