Mitochondrial DNA Damage Does Not Determine <i>C. elegans</i> Lifespan.

However, when we quantified the levels of mtDNA damage in daf-2 mutants, we found that mtDNA damage levels were not lower than wild type N2 controls but were in fact threefold higher in daf-2 mutants relative to wild type N2 controls and this elevation was statistically highly significant ( Figure 6 , p < 0.0001, Student’s t -test).

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However, similar to our PCR-based mtDNA damage assay, post-test reveals that the percentage of DNA in the comet tail of the nematodes challenged with 20 kRad γ-irradiation showed a trend to increased damage but this increase individually is not significant relative to the non-irradiated control nematodes ( Figure 3B , p = 0.08, Student’s t -test).

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