Replicating Adenovirus-SIV Immunization of Rhesus Macaques Induces Mucosal Dendritic Cell Activation and Function Leading to Rectal Immune Responses.

Moreover, rectal mDCs after the 1st Ad-SIV immunization exhibited highly significant positive correlations with rectal IFN-γ + CD8 + memory T cells specific for SIV Gag ( r = 0.7356, p = 0.0002), SIV M766 Env ( r = 0.5979, p = 0.0054), and SIV CG7V Env ( r = 0.7615, p < 0.0001).

also in 132,142 other papers

Nevertheless, after 6-days of co-culture and 6 h of Env peptide pool stimulation, T cells co-cultured with DCs from Ad-SIV-immunized macaques showed enhanced frequencies of cytokine + cells approaching significance compared to those co-cultured with DCs from macaques that received Ad-Empty vectors ( Figure 9C ).

also in 2,640 other papers