The Discovery and Development of Liraglutide and Semaglutide.

Front Endocrinol (Lausanne) · 2019 · PMC6474072 · PMID 31031702

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a clear trendno p-value reported

This phenomenon had previously been observed with liraglutide analogs, where there was a clear trend for longer fatty acids, with improved affinity for albumin, to be associated with diminished potency for the GLP-1R ( 53 ).

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