Metabolic Risk Factors and Left Ventricular Diastolic Function in Middle-Aged Chinese Living in the Tibetan Plateau.

The previously published post hoc analysis of the COURAGE (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation) trial of 2287 subjects showed that for each end point (fatal or nonfatal myocardial infarction, heart failure, percutaneous coronary intervention), there was a significant trend for increasing risk as the metabolic risk factor number increased. 28 However, in the stratified multivariable analysis by age, we found that even 2 risk factors clustering was associated with a higher risk in the middle‐age group; however, more metabolic risk factors clustering was not significantly associated with greater risk of LVDD for the elderly participants.

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