A Novel Dipeptide NGF Mimetic GK-2 Selectively Activating the PI3K/AKT Signaling Pathway Promotes the Survival of Pancreatic β-Cells in a Rat Model of Diabetes.

Acta Naturae · 2019 · PMC6475863 · PMID 31024748

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4 ). DISCUSSION An important trend in modern diabetology is the search for ways to protect β-cells from the damaging effects of metabolic changes characteristic of T2DM: lipoglucotoxicity, oxidative stress, DNA alkylation, ATP deficiency, and reduced levels of mature neurotrophins [ 34 , 35 ].

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